Brugada Syndrome – Clinical Case

A 20-year-old male is brought in by his mother, after she witnessed a collapse at home.

She states that he had a fever that morning and was witnessed to collapse while walking towards the bathroom. He was unconscious for about a minute and thereafter became fully responsive.

Which of these history features is most suggestive of Brugada syndrome?

The mother states the patient was unresponsive but had no other alarming features during the episode. The patient could not recall any preceding symptoms. He had a paternal uncle who died of a “heart problem” at the age of 35-but no more details are available.

Which 1 investigation will be the most useful in establishing the diagnosis in this patient?

An ECG is performed and is shown below.

Fig.3 from LIFL¹²

What is the diagnosis?

In the initial management of this patient, which is the most important first step?

Which of the following drugs combinations would you avoid when treating this patient if he required procedural sedation during an unrelated visit?