Acute Liver Failure Case 2
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Question 1 of 3
1. Question
A 43-year-old male recently started on phenytoin for epilepsy presents to the ED complaining of abdominal pain.
- He has no signs of chronic liver disease
- He has hepatic tenderness
- His INR is 6.0 with an ALT of 9400
You:
- Recognise he is in acute liver failure
- Resuscitate him as indicated
- Refer him to the tertiary referral centre
What are the two specific treatments in this case?
CorrectIncorrect -
Question 2 of 3
2. Question
Drug detoxification is only one of the roles of the liver. How would you describe the other roles?
Match the pathological manifestation with the normal function.
Sort elements
- Hypoglycaemia
- Hyperammonemia causing encephalopathy
- Jaundice
- Coagulopathy and hypoalbuminaemia
- Increased sepsis
- Altered perception of volume status and subsequent renal failure
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Carbohydrate metabolism
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Protein metabolism
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Bile secretion
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Protein synthesis and secretion
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Clearance of gut bacteria from portal system
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Sodium and water balance
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Question 3 of 3
3. Question
Rank the following drug groups to those most commonly causing acute liver failure.
Question scoring: Points are deducted for selecting incorrect options.
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Anti-TB drugs
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Herbals/dietary supplements
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Antiepileptics (phenytoin, valproate)
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Antibiotics (nitrofurantoin, ciprofloxacin, itraconazole, doxycycline, Co-amoxiclav)
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Sulfa drugs (sulfasalazine, cotrimoxazole)
CorrectIncorrect