Key Learning Points
- GBS is a spectrum of diseases affecting both the axon and myelin sheath.
- A post-infectious presentation is common, particularly Campylobacter Jejuni gastroenteritis.
- Typical GBS presents with rapidly progressive symmetrical ascending weakness and reduced or absent reflexes.
- Presentation may be subtle, especially in children, with pain, gait disturbance, or refusal to walk. GBS should be considered in the differential diagnosis of the limping child.
- Fever at presentation, raised CSF white cell count (WCC), atypical features, or relevant travel history should prompt consideration of alternative diagnoses.
- All suspected cases should be referred for admission
- ICU care may be required for patients with significant respiratory problems
- ECG and blood pressure monitoring are required
- Severe cases should be treated with IVIG
- Corticosteroids have no proven benefit in GBS.
- Prognosis in children is generally very good