The commonest cause of acute dystonia is prescribed medication. Usually such cases present shortly after initiation of drug treatment, with 50% occurring within 48 hours, and 90% within five days of initiation of therapy.
Medications most commonly associated with this phenomenon are:
Acute dystonia is more common with selective serotonin re-uptake inhibitors (SSRIs) than with other antidepressants e.g. tricyclics. Moreover, antipsychotic serum levels can increase when SSRIs are added to therapy.
The majority of acute dystonias occur within the first seven days of commencing medication. Evidence Grade 2B