Power, Sample Size, and Significance
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1. Question
The authors calculated that a sample size of 1000 in each of the three arms would give 90% power to detect an absolute difference of 6.3% in the probability of survival to hospital discharge. They were able to analyse data for 970 in the Amiodarone arm, 985 in the Lidocaine arm, and 1056 in the placebo arm.
There was a 3.2% improvement in survival to discharge when comparing the Amiodarone and placebo groups; the difference did not reach significance at the 95% level.
Which of the following statements is true?
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