Combined Beta Blocker and Calcium Channel Blocker Overdose

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Author: Shehab Elmoghazy, Ahmed Said / Editor: Stephen Sheridan / Codes: / Published: 16/01/2026

A 38-year-old female patient presents to the emergency department (ED) with an overdose of Bisoprolol 15 10 mg (150 mg total) and Amlodipine 15 10 mg (150 mg total). She reported that the time of ingestion was 4 hours ago.

Examination findings:

  • Airway patent; speaking in full sentences but drowsy (GCS 14)
  • Respiratory rate 18 min , SpO 98 % on air
  • BP 60/40 mmHg, HR 30 bpm (sinus bradycardia)
  • Capillary blood glucose 2.5 mmol L
  • Peripheral cool; capillary refill > 4 s
  • ECG: sinus bradycardia, PR prolongation (220 ms), narrow QRS
  • Initial venous blood gas: pH 7.18, lactate 6.5 mmol L , K 3.2 mmol L

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