Malaria

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Author: Wallisa Roberts / Editor: Sandi Angus / Codes: / Published: 23/04/2026

Malaria is the most common, imported tropical disease in the UK. Patients with a history of recent travel from malaria endemic regions should be screened for the plasmodium parasite via thick/thin blood films. None of the scoring systems have been validated for use in classifying imported malaria. Currently, intravenous artesunate is the first line treatment for severe malaria. However, local Infectious Disease specialists should be consulted prior to commencing treatment. The most common complications of severe malaria requiring ITU admission include ARDS, AKI and cerebral malaria.

This module covers the epidemiology, pathophysiology and lifecycle of Malaria, alongside recognising and managing severe cases and initiating appropriate treatment.

Learning objectives

After completing this session, you will be able to:

  • Understand the epidemiology of malaria.
  • Understand the patient demographics of imported malaria.  
  • Understand the life cycle of the plasmodium parasite.
  • Understand the pathophysiology of malaria.
  • Identify the sick malarial patient.
  • Effectively manage patients presenting with severe malaria

References

  1. World Health Organization. Malaria. Geneva: WHO; 2025 Dec 4. [cited 10 Nov 2025].
  2. Samarasekera U. Climate change and malaria: predictions becoming reality. The Lancet. 2023 Jul 29; 402 (10399).
  3. UK Health Security Agency. Malaria imported into the UK: 2021 [internet]. 2023 [cited 19 Oct 2023].
  4. Marks ME, Armstrong M, Suvari MM, Batson S, et al. Severe imported falciparum malaria among adults requiring intensive care: a retrospective study at the hospital for tropical diseases, London. BMC Infect Dis. 2013 Mar 03; 13(118).
  5. Sato S. Plasmodium a brief introduction to the parasites causing human malaria and their basic biology. J Physiol Anthropol. 2021 Jan 07; 40(1).
  6. Tatem AJ, Jia P, Ordanovich D, Falkner M, Huang Z, Howes R. The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics. The Lancet. 2016 Oct 21; 17(1): P98-107. [cited 23 Oct 2023].
  7. Greenwood BM, Fidock DA, Kyle DE, Kappe SHI, et al. Malaria: progress, perils, and prospects for eradication. JCI 2008 Apr 1; 11(4): 1266-1276. Image C Life cycle of the plasmodium parasite causing malaria; [cited 24 Oct 2023].
  8. Mawson AR. The pathogenesis of malaria: a new perspective. Pathog Glob Health. 2013 April; 107(3): 122-129.
  9. Mishra SK, Panigrahi P, Mishra R, Mohanty S. Prediction of outcomes in adults with severe falciparum malaria: a new scoring system. Malar J. 2007 Feb 27; 6(24).
  10. Centers for Disease Control and Prevention (CDC). Malaria: Image gallery. CDC, Last reviewed 2024 Sept.
  11. UK Health Security Agency. Guiedelines for the malaria prevention in travellers from the UK 2024. UKHSA.
  12. Bailey P, Behrens R, Brown M, Checkley A, Chiodini P, et al. Malaria diagnosis and treatment guideline. HTD. Last updated 2016 Nov 07.

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