Acute Opioid Toxicity

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Author: Sangeeta Khadka, William Wilson / Editor: Tim Osborne / Codes: Published: 17/09/2025

A 32-year-old male is brought to the Emergency Department (ED) by ambulance. According to the paramedics, he was found unconscious on the floor by a friend, with empty packets of codeine and clobazam tablets and a bottle of oral morphine next to him.

Upon initial assessment his observations are:

  • HR: 68 beats per minute
  • BP: 110/66
  • RR: 7 breaths per minute
  • SpO2: 90% breathing air
  • GCS E3 V4 M5
  • Pupils 1mm reactive bilaterally

The nursing team has already initiated oxygen therapy, and intravenous (IV) access is established.

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