Drug Related Hyperthermia

Author: Claire Louise Kirby / Editor: Steven Bland / Reviewer: Louise Burrows, Emma Everitt / Codes: A4, CC2 / Published: 27/10/2022

Drugs associated with altered temperature regulation and including hyperthermia.

After completing this session you will be able to:

  • List drugs associated with altered temperature regulation and including hyperthermia.
  • Describe the presentation of a patient with hyperthermia and associated syndromes.
  • Describe the initial assessment and management of hyperthermia.
  • Describe the specific management of hyperthermia associated with serotonergic syndrome, neuroleptic malignant syndrome, adverse drug reactions and withdrawal.
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References:

  1. Mechem CC. Severe nonexertional hyperthermia (classic heat stroke) in adults. UpToDate, April 2021.
  2. Halloran LL, Bernard DW. Management of drug-induced hyperthermia. Curr Opin Pediatr. 2004 Apr;16(2):211-5.
  3. Musselman ME, Saely S. Diagnosis and treatment of drug-induced hyperthermia. Am J Health Syst Pharm. 2013 Jan 1;70(1):34-42.
  4. Hadad E, Weinbroum AA, Ben-Abraham R. Drug-induced hyperthermia and muscle rigidity: a practical approach. Eur J Emerg Med. 2003 Jun;10(2):149-54.
  5. Ables AZ, Nagubilli R. Prevention, recognition, and management of serotonin syndrome. Am Fam Physician. 2010 May 1;81(9):1139-42.
  6. Isbister GK, et al. Serotonin toxicity: a practical approach to diagnosis and treatment. Med J Aust. 2007 Sep 17;187(6):361-5.
  7. Perry PJ, Wilborn CA. Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management. Ann Clin Psychiatry. 2012 May;24(2):155-62.
  8. Dunkley EJ, Isbister GK, et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003 Sep;96(9):635-42.
  9. Wijdicks E. Neuroleptic malignant syndrome. UpToDate, May 2022.
  10. Levenson JL. Neuroleptic malignant syndrome. Am J Psychiatry. 1985 Oct;142(10):1137-45.
  11. Su M, Goldman M. Anticholinergic poisoning. UpToDate, July 2012.
  12. Rosenberg H, Davis M, et al. Malignant hyperthermia. Orphanet J Rare Dis. 2007 Apr 24;2:21.
  13. Kim DC. Malignant hyperthermia. Korean J Anesthesiol. 2012 Nov;63(5):391-401.
  14. Boyer EW. Serotonin syndrome (serotonin toxicity). UpToDate, June 2022.

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