Parkinson’s Disease

Author: Cliff Mann / Editor: David Leverton / Reviewer: Michael Perry, Raja Shahid Ali / Codes: / Published: 11/04/2023

Parkinson’s disease is a common neurodegenerative disease affecting adults. Symptoms and disability can arise as a result of the disease itself and the complications of medical therapy.

By the end of this session you will be able to:

  • Describing the key features of Parkinsons disease including the incidence, symptoms and natural progression of the disease, as well as investigative and treatment strategies.
  • Contrast the differences between Parkinsonism and Parkinson’s disease
  • Give examples of important differential diagnoses
  • Outline the pharmacological treatment of Parkinson’s disease
  • Explain the most important complications of pharmacological therapy

References:

  1. Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol. 1999 Jan;56(1):33-9.
  2. Parkinson J. An essay on the shaking palsy. 1817. J Neuropsychiatry Clin Neurosci. 2002 Spring;14(2):223-36; discussion 222.
  3. Jankovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatr 2008;79:368-376.
  4. Caballol N, Mart MJ, Tolosa E. Cognitive dysfunction and dementia in Parkinson disease. Mov Disord. 2007 Sep;22 Suppl 17:S358-66.
  5. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427-442.
  6. National Institute for Health and Care Excellence. Parkinsons disease in adults. NICE guideline [NG71], 2017.
  7. Scottish Intercollegiate Guideline Network. Guideline 113. Diagnosis and pharmacological management of Parkinson’s disease. 2010; Edinburgh: SIGN.
  8. Rajput AH, Rozdilsky B, Rajput A. Accuracy of clinical diagnosis in parkinsonism–a prospective study. Can J Neurol Sci. 1991 Aug;18(3):275-8.
  9. Specialist Pharmacy Service. Reducing harm from omitted or delayed medicines in hospital. Source UK Medicines Information, 2020. Last updated 10 May 2022.

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